Profhilo is a hyaluronic acid bio-remodeller — it hydrates, tightens, and stimulates collagen through HA spreading beneath the skin. Rejuran is a salmon DNA (PDRN) skin healer — it repairs damaged cells at the DNA level and reduces inflammation. Profhilo is better for laxity and hydration. Rejuran is better for scarring, dark circles, and damaged skin. They can be combined for comprehensive rejuvenation.

See also: Profhilo vs skin boosters · Profhilo vs polynucleotides · Profhilo vs exosomes · Profhilo vs mesotherapy

Profhilo is the better first choice when your primary concern is skin laxity, loss of firmness, or overall dehydration. It contains 64mg of hybrid hyaluronic acid that spreads beneath the skin to stimulate four types of collagen and elastin. The result is visibly tighter, more hydrated, and more luminous skin.

Profhilo requires only 2 sessions (vs 3–4 for Rejuran), has a highly predictable response, and is clinically proven for the face, neck, hands, and décolletage. It is Dr Azra’s go-to for patients aged 30–50 whose primary complaint is “my skin doesn’t look as firm or fresh as it used to.” For pricing, see the Profhilo pricing page.

Rejuran is the better choice when your skin needs repair rather than just hydration. PDRN works through the DNA salvage pathway — providing nucleotides that damaged cells need to reconstruct their DNA. It also activates adenosine A2A receptors for anti-inflammatory effects, making it excellent for sensitised, sun-damaged, or post-inflammatory skin.

Choose Rejuran for acne scarring, dark circles, enlarged pores, chronic redness, sun-damaged skin, or when surface treatments like skin boosters haven’t delivered enough improvement. Rejuran I (Eye) is specifically formulated for the delicate periorbital area. For more on the science, read what is PDRN and what are polynucleotides.

In Dr Azra’s clinical practice, Profhilo and Rejuran address different layers of skin ageing. Profhilo rebuilds structural hydration and firmness. Rejuran repairs cellular damage and reduces inflammation. For patients with both concerns — which is most patients over 35 in Dubai’s climate — Dr Azra designs a protocol that alternates both treatments.

A common approach is starting with Profhilo (2 sessions) for visible tightening and glow, then layering Rejuran (3–4 sessions) for deeper cellular repair. The combination addresses skin quality at both the structural and biological level — delivering results that neither treatment achieves alone. The best sequence is determined during consultation based on your skin assessment.