Profhilo is a hyaluronic acid bio-remodeller — it hydrates, tightens, and stimulates collagen through HA spreading beneath the skin. Rejuran is a salmon DNA (PDRN) skin healer — it repairs damaged cells at the DNA level and reduces inflammation. Profhilo is better for laxity and hydration. Rejuran is better for scarring, dark circles, and damaged skin. They can be combined for comprehensive rejuvenation.

See also: Profhilo vs skin boosters · Profhilo vs polynucleotides · Profhilo vs exosomes · Profhilo vs mesotherapy

Profhilo is the better first choice when your primary concern is skin laxity, loss of firmness, or overall dehydration. It contains 64mg of hybrid hyaluronic acid that spreads beneath the skin to stimulate four types of collagen and elastin. The result is visibly tighter, more hydrated, and more luminous skin.

Profhilo requires only 2 sessions (vs 3–4 for Rejuran), has a highly predictable response, and is clinically proven for the face, neck, hands, and décolletage. It is Dr Azra’s go-to for patients aged 30–50 whose primary complaint is “my skin doesn’t look as firm or fresh as it used to.” For pricing, see the Profhilo pricing page.

Rejuran is the better choice when your skin needs repair rather than just hydration. PDRN works through the DNA salvage pathway — providing nucleotides that damaged cells need to reconstruct their DNA. It also activates adenosine A2A receptors for anti-inflammatory effects, making it excellent for sensitised, sun-damaged, or post-inflammatory skin.

Choose Rejuran for acne scarring, dark circles, enlarged pores, chronic redness, sun-damaged skin, or when surface treatments like skin boosters haven’t delivered enough improvement. Rejuran I (Eye) is specifically formulated for the delicate periorbital area. For more on the science, read what is PDRN and what are polynucleotides.

In Dr Azra’s clinical practice, Profhilo and Rejuran are used for different skin concerns — neither is universally better.
Profhilo is mainly used for hydration, glow, and mild firmness, while Rejuran focuses on skin repair, texture improvement, and inflammation.

For many patients in Dubai — especially over the age of 30–35 — a combination approach may be recommended depending on skin condition.
A common protocol is starting with Profhilo (2 sessions) for visible hydration and tightening, followed by Rejuran (3–4 sessions) for deeper cellular repair.
The exact sequence is determined during consultation based on your skin assessment.