Skin · Polynucleotides · Dubai & Abu Dhabi

Polynucleotide Treatment in Dubai

Polynucleotides represent the next generation of regenerative skin treatments — repairing damaged cells, stimulating fibroblast activity, and restoring skin quality from within. Dr Azra Vaziri now offers polynucleotide therapy using Rejuran (Vitaran) for patients seeking deep biological skin regeneration beyond what skin boosters and Profhilo can achieve alone.

Procedure Time
20–30 minutes
Recovery
Minimal — 1–2 days
Treatment Areas
Face, undereye, neck, hands
Results
Progressive, 6–12 months

What Are Polynucleotides

Polynucleotides (PN) are fragments of DNA derived from salmon or trout DNA that act as powerful biological repair signals when injected into the skin. Unlike hyaluronic acid skin boosters that primarily hydrate, or biostimulators that trigger collagen through inflammatory response, polynucleotides work at the cellular level — activating fibroblasts, promoting tissue repair, reducing inflammation, and scavenging free radicals.

The result is genuine skin regeneration: improved elasticity, reduced fine lines, better texture, and a healthier skin structure. For a deeper explanation, see our complete guide to polynucleotides.

Dr Azra uses Rejuran (Vitaran) — a highly purified polynucleotide derived from salmon DNA (PDRN). Patients familiar with salmon DNA treatments will recognise polynucleotides as the next evolution of this approach.

How Polynucleotides Work
  • Activate fibroblasts to produce new collagen and elastin
  • Promote cellular repair and tissue regeneration (wound healing pathway)
  • Anti-inflammatory and free radical scavenging properties
Clinical Benefits

Polynucleotides vs Profhilo vs Skin Boosters

How do polynucleotides compare with other injectable skin-quality treatments?

FeaturePolynucleotidesProfhiloSkin BoostersPRP
Active IngredientSalmon DNA fragments (PDRN)High-concentration HA (64mg)Hyaluronic acid micro-gelYour own platelet growth factors
MechanismCellular repair & fibroblast activationBio-remodelling & hydrationDermal hydrationGrowth factor stimulation
Primary BenefitTissue regeneration & anti-inflammationSkin laxity & firmnessGlow, hydration, plumpingCollagen induction & repair
Best ForDamaged skin, undereye, ageingSkin laxity, neck, firmnessDehydrated skin, dullnessScars, ageing, hair loss
Sessions3–4, every 2–4 weeks2, one month apart2–3, monthly3–4, every 4–6 weeks
Duration6–12 months6–9 months4–6 months6–12 months
DowntimeMinimal (1–2 days)Minimal (bumps 24hr)Minimal (hours–1 day)Mild (24–48hr)

These treatments are complementary. Dr Azra often combines polynucleotides with Profhilo or PRP. See: Profhilo vs Booster vs Polynucleotides.

Treatment Areas

Polynucleotides can be applied to multiple areas where skin quality, elasticity, and regeneration are needed.

Face

Full face3–4 sessions

Overall skin quality improvement, elasticity restoration, fine line reduction. Ideal for dull skin or early aging.

Undereye

Tear trough3–4 sessions

Dark circles and crepey undereye skin. Polynucleotides thicken thin periorbital skin where fillers may not be appropriate. Complementary to undereye filler.

Neck & Hands

Décolletage3–4 sessions

Neck wrinkle correction and hand rejuvenation. Thin, sun-damaged skin responds well to polynucleotide tissue repair.

How Polynucleotide Treatment Works

1

Consultation

Skin assessment and personalised plan with Dr Azra.

2

Preparation

Skin cleansing and topical numbing cream applied to treatment area.

3

Injection

Polynucleotides injected using fine needles via micro-injection technique. 20–30 minutes.

4

Results

Progressive improvement over 2–4 weeks per session. Full protocol: 3–4 sessions.

Polynucleotides Compared with Other Treatments

vs Profhilo

Polynucleotides vs Profhilo

Profhilo hydrates and provides mild biostimulation. Polynucleotides repair at the cellular level. Different mechanisms, often combined. Full comparison →

vs Skin Boosters

Polynucleotides vs Skin Boosters

Skin boosters deliver HA hydration. Polynucleotides deliver DNA-based tissue repair. Direct comparison → · Three-way comparison →

vs PRP

Polynucleotides vs PRP

PRP uses your own growth factors. Polynucleotides deliver standardised DNA repair signals. Complementary treatments.

vs Exosomes

Polynucleotides vs Exosomes

Exosomes deliver growth factors and signalling proteins. Polynucleotides deliver DNA repair fragments. Often layered together. Full comparison → · Regenerative comparison →

Who Is a Good Candidate

Suitable Candidates
  • Patients with early skin aging seeking deep regeneration
  • Fine lines and loss of skin elasticity
  • Dark circles and crepey undereye skin
  • Sun-damaged or dehydrated skin (neck, décolletage, hands)
  • Patients wanting to enhance results of Profhilo or skin boosters
  • Acne scar improvement (as adjunctive therapy)
Postpone Until Medical Review
  • Pregnancy or breastfeeding
  • Active skin infection at treatment site
  • Known allergy to fish-derived products
  • Autoimmune conditions (requires assessment)
  • Active cancer treatment

A consultation with Dr Azra helps determine suitability.

Treatment Care Guidelines

Before Treatment
  • Avoid blood thinners (aspirin, ibuprofen, fish oil) for 1 week
  • Avoid alcohol for 48 hours before
  • Arrive with clean, makeup-free skin
  • Inform Dr Azra of allergies — especially fish/seafood
  • Disclose all medications and medical conditions
After Treatment
  • Mild redness and small bumps — resolve within 24–48 hours
  • Avoid makeup for 12 hours
  • Avoid heat (sauna, steam, hot yoga) for 48 hours
  • Avoid intense exercise for 24 hours
  • No facial treatments or chemical peels for 2 weeks
  • Protect skin from direct sun — SPF 50 daily

Related Treatments

Treatment

Profhilo

HA bioremodelling.

Treatment

Skin Boosters

Hydration and glow.

Treatment

Exosome Therapy

Cellular repair.

Treatment

Dermapen

Microneedling + serums.

Treatment

Mesotherapy

Vitamin microinjections.

Educational Guides

Guide

What Are Polynucleotides?

Complete science guide.

Comparison

Profhilo vs Boosters vs PN

Three-way comparison.

Guide

What Is PDRN?

PDRN therapy explained.

Guide

Dermapen Serums Guide

Serum selection for needling.

Guide

Salmon DNA Facial

DNA-based skin therapy.

Frequently Asked Questions

What are polynucleotides?

Polynucleotides are fragments of DNA (typically derived from salmon) that act as biological repair signals when injected into the skin. They activate fibroblasts, stimulate collagen and elastin production, reduce inflammation, and promote tissue regeneration at the cellular level. This makes them fundamentally different from skin boosters (hydration) or biostimulators (collagen via inflammation). Read our complete guide for the full science.

Dr Azra uses Rejuran (Vitaran) — a highly purified polynucleotide derived from salmon DNA (PDRN). Rejuran is one of the most clinically studied polynucleotide products globally, with an established safety and efficacy profile for skin regeneration, dark circles, and overall skin quality improvement.

Profhilo is a hyaluronic acid bioremodeller that hydrates and provides mild collagen stimulation. Polynucleotides are DNA fragments that repair cells, reduce inflammation, and regenerate tissue through a completely different biological pathway. They are complementary and often combined for a layered approach. Full comparison →

Most patients require 3 to 4 sessions spaced 2 to 4 weeks apart. Results develop progressively as the biological repair process takes effect. Maintenance sessions every 4 to 6 months help sustain results long-term.

Face (full face skin quality), undereye area (dark circles and crepey skin), neck, décolletage, and hands. Particularly effective for thin, damaged skin where fillers are not appropriate.

Yes. Polynucleotides derived from salmon DNA have been used in aesthetic and medical applications for years. The DNA fragments are highly purified and biocompatible. Side effects are mild — temporary redness, small bumps, and mild swelling that typically resolve within 24 to 48 hours. Patients with fish allergies should inform Dr Azra prior to treatment.

Yes. Dermapen microneedling creates micro-channels that enhance polynucleotide absorption into the dermis. This combination delivers both collagen induction (from microneedling) and cellular repair (from polynucleotides) simultaneously. Dr Azra may also apply polynucleotides as a treatment serum during Dermapen. See Dermapen pricing for combination costs.

Yes. Polynucleotides combine well with Profhilo (hydration + repair), skin boosters (glow + regeneration), PRP (growth factors + DNA repair), exosomes (layered regenerative approach), Dermapen microneedling (enhanced delivery), and mesotherapy (vitamin cocktails). Dr Azra designs combination protocols based on each patient’s goals.

Initial improvement in skin texture and radiance is typically visible within 2 to 3 weeks after the first session. Full results develop progressively over the treatment course (3–4 sessions) and continue to improve for several weeks after the final session. Results last 6 to 12 months. For comparison, see Dermapen before and after timelines.

They are closely related. Salmon DNA treatments typically refer to PDRN (polydeoxyribonucleotide) — a specific fraction of polynucleotides with a defined molecular weight. Rejuran uses PDRN extracted from salmon DNA. The terms are often used interchangeably in aesthetic marketing, though there are subtle scientific distinctions. Salmon DNA facial explained →

Polynucleotide treatment pricing with Dr Azra Vaziri depends on the treatment area and number of sessions. Pricing is discussed during consultation with package options available. Contact the clinic to book.

Book A Consultation With Dr Azra

Patients seeking personalized aesthetic assessment in Dubai or Abu Dhabi can contact Dr Azra for consultation regarding PRP, exosome therapy, and regenerative skin treatment planning.

Dr Azra Vaziri is a DHA and DOH licensed aesthetic physician practicing in Dubai and Abu Dhabi, with over 20 years of experience in aesthetic medicine, injectables, thread lifting, and non-surgical facial rejuvenation.